Brinzolamide

White to beige powder. Soluble in DMSO (30mg/ml). Insoluble in water or ethanol. Chemical. CAS: 138890-62-7. Formula: C12H21N3O5S3. MW: 383.51. Synthetic. Brinzolamide is a potent inhibitor of carbonic anhydrases (IC50=3.2nM and 45.3nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion. Animal studies have found that one week of twice-daily topical ocular treatment with 2% brinzolamide significantly reduced IOP and enhanced optic nerve head blood flow.