BRD7552

BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as PDX1 protein levels, in PANC-1 cells. It also increases acetylation of histone H3 and trimethylation of H3K4 and H3K9.Formal Name: 2,3-bis(N-1,3-benzodioxol-5-ylcarbamate), 4-[N-[4-(ethoxycarbonyl)phenyl]carbamate], methyl, alpha-D-glucopyranoside. CAS Number: 1137359-47-7. Molecular Formula: C33H33N3O15. Formula Weight: 711.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 252 nm. SMILES: O=C(O[C@H]1[C@H](OC(NC2=CC=C(C=C2)C(OCC)=O)=O)[C@H](O[C@H](OC)[C@@H]1OC(NC3=CC=C4C(OCO4)=C3)=O)CO)NC5=CC=C6C(OCO6)=C5. InChi Code: InChI=1S/C33H33N3O15/c1-3-43-29(38)17-4-6-18(7-5-17)34-31(39)49-26-25(14-37)48-30(42-2)28(51-33(41)36-20-9-11-22-24(13-20)47-16-45-22)27(26)50-32(40)35-19-8-10-21-23(12-19)46-15-44-21/h4-13,25-28,30,37H,3,14-16H2,1-2H3,(H,34,39)(H,35,40)(H,36,41)/t25. InChi Key: AAOLIMLEFKWKOY-IXMSMLDRSA-N.