Brazilin

Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. Brazilin inhibits Abeta (1-42) fibrillogenesis (IC50 = 1.5 µM) more potently than (-)-epigallocatechin gallate (Cay-70935), cucurmin (Cay-81025), and resveratrol (Cay-10004235, Cay-70675). It also prevents remodeling of mature Abeta (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 (Cay-14010) and TNF-alpha (IC50s = 12.6 and 87.2 µM). It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 µg/ml. In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.Formal Name: 7,11bR-dihydro-benz[b]indeno[1,2-d]pyran-3,6aS,9,10(6H)-tetrol. CAS Number: 474-07-7. Synonyms: (+)Brazilin, NSC 56652. Molecular Formula: C16H14O5. Formula Weight: 286.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 290 nm. SMILES: OC(C=C1)=CC2=C1[C@](C(C=C(O)C(O)=C3)=C3C4)([H])[C@]4(O)CO2. InChi Code: InChI=1S/C16H14O5/c17-9-1-2-10-14(4-9)21-7-16(20)6-8-3-12(18)13(19)5-11(8)15(10)16/h1-5,15,17-20H,6-7H2/t15-,16+/m0/s1. InChi Key: UWHUTZOCTZJUKC-JKSUJKDBSA-N.