Bosentan

Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).Formal Name: 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide. CAS Number: 147536-97-8. Synonyms: Ro 47-0203. Molecular Formula: C27H29N5O6S. Formula Weight: 551.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 12 mg/ml, Ethanol: 11 mg/ml. lambdamax: 215, 267 nm. SMILES: COC1=CC=CC=C1OC2=C(NS(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)N=C(C4=NC=CC=N4)N=C2OCCO. InChi Code: InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32). InChi Key: GJPICJJJRGTNOD-UHFFFAOYSA-N.