Boc-Asp(OMe)-FMK

White to off-white powder. Soluble in ethanol (5mg/ml), DMSO or DMF (both 30mg/ml). Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies, Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor, Inhibits the pro-apoptotic effect of TNF-alpha (IC50=39µM). Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1, Blocks hepatocyte apoptosis in vivo, Neuroprotective.