Bisindolylmaleimide V

Bisindolylmaleimide V (BIM V) is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 µM. While effectively inactive as a PKC inhibitor, BIM V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM.Formal Name: 3,4-di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione. CAS Number: 113963-68-1. Synonyms: BIM V, Ro 31-6045. Molecular Formula: C21H15N3O2. Formula Weight: 341.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 278, 375, 471 nm. SMILES: O=C1C(=C(c2c[nH]c3ccccc23)C(=O)N1C)c1c[nH]c2ccccc12. InChi Code: InChI=1S/C21H15N3O2/c1-24-20(25)18(14-10-22-16-8-4-2-6-12(14)16)19(21(24)26)15-11-23-17-9-5-3-7-13(15)17/h2-11,22-23H,1H3. InChi Key: SWAWYMIKGOHZMR-UHFFFAOYSA-N.