(Bis(trifluoroacetoxy)iodo)benzene

(Bis(trifluoroacetoxy)iodo)benzene (BTIB, PIFA) is a hypervalent iodine reagent widely used as a mild and selective oxidizing agent in organic synthesis. It facilitates oxidative transformations such as phenol coupling, dearomatization, alpha-oxygenation of carbonyl compounds, and heterocycle formation under mild conditions, often avoiding harsh metal-based oxidants. (Bis(trifluoroacetoxy)iodo)benzene is also employed in peptide and carbohydrate chemistry for oxidative cleavage and functionalization of sensitive substrates.