Bis-T-23

Description: Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD). Target: HIV Protease. Smiles: C(=C(/C(NCCCNC(/C(=C/C1=CC(O)=C(O)C(O)=C1)/C#N)=O)=O)\C#N)\C2=CC(O)=C(O)C(O)=C2. References: Sever S, Schiffer M. Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases. Kidney Int. 2018 Jun , 93(6):1298-1307. doi: 10.1016/j.kint.2017.12.028. Epub 2018 Apr 17. Review. PubMed PMID: 29678354 , PubMed Central PMCID: PMC5967993.