BIA 10-2474

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme). It also inhibits FAAH2, alpha/beta-hydrolase domain-containing protein 6 (ABHD6), carboxylesterase 2 (CES2), and patatin-like phospholipase domain 6 (PNPLA6) with IC50 values of 0.4, 0.081, 2, and 11 µM, respectively. BIA 10-2474 alters expression of 161 lipid species, including FAAH substrates as well as other lipid classes, in human cortical neuron cultures indicating compound promiscuity. Formulations containing BIA 10-2474 were previously investigated clinically for the management of chronic pain but use was halted due to development of significant neurotoxicity.Formal Name: N-cyclohexyl-N-methyl-4-(1-oxido-3-pyridinyl)-1H-imidazole-1-carboxamide. CAS Number: 1233855-46-3. Molecular Formula: C16H20N4O2. Formula Weight: 300.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 213, 263 nm. SMILES: CN(C(N1C=NC(C2=C[N+]([O-])=CC=C2)=C1)=O)C3CCCCC3. InChi Code: InChI=1S/C16H20N4O2/c1-18(14-7-3-2-4-8-14)16(21)19-11-15(17-12-19)13-6-5-9-20(22)10-13/h5-6,9-12,14H,2-4,7-8H2,1H3. InChi Key: DOWVMJFBDGWVML-UHFFFAOYSA-N.