BI-4732

Description: BI-4732 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with high blood-brain barrier permeability, antitumor activity, inhibition of EGFR activation, and inhibition of T790M mutations. Target: EGFR. Smiles: CN1C=2C(=C(N=C(C2)N3C=4C(C=N3)=C(C)N=C(C4)C=5C(OC)=CC=NC5)N6[C@@]7(C[C@](C6)(OC7)[H])[H])N=C1N8C[C@@]9(N(CC8)CCC9)[H]. References: Lee EJ, et al. Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC. Clin Cancer Res. 2024 Apr 15,30(8):1582-1594.