Bexotegrast

Description: Bexotegrast (PLN-74809) is an orally active and potent inhibitor of alphavbeta6 and alphavbeta1 integrins with antifibrotic effects, inhibiting alphavbeta6 and alphavbeta1-induced activation of TGF-beta. It is applicable for studies of idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP). Target: Integrin. Smiles: N([C@@H](CCN(CCCCC=1NC=2C(=CC1)CCCN2)CCOC)C(O)=O)C=3C4=C(N=CN3)C=CC=C4. References: Anindya Roy, et al. De novo design of highly selective miniprotein inhibitors of integrins alphavbeta6 and alphavbeta8. Nat Commun. 2023 Sep 13,14(1):5660.