Betulinic acid

Description: Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase. Target: Apoptosis, HIV Protease, Aminopeptidase, Autophagy, Topoisomerase, Mitophagy, Endogenous Metabolite, NF-kappaB. Smiles: C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@H](O)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]. References: Fujioka T, et al. J Nat Prod, 1994, 57(2), 243-247.