beta-Mangostin

beta-Mangostin is a xanthone originally isolated from G. mangostana with diverse biological activites. It inhibits growth of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA, MICs = 6.25-12.5 and 6.25-25 µg/ml, respectively), P. falciparum (IC50 = 3 µg/ml), and M. tuberculosis (MIC = 6.25 µg/ml). beta-Mangostin inhibits fatty acid synthase (FASN) with an IC50 value of 24.83 µM. It induces cell cycle arrest at the G2/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells. beta-Mangostin also inhibits LPS-induced nitric oxide and prostaglandin E2 (PGE2, Cay-14010) production in RAW264.7 cells and reduces neutrophil infiltration and TNF-alpha and IL-1beta production in a mouse model of carrageenan-induced peritonitis.Formal Name: 1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one. CAS Number: 20931-37-7. Molecular Formula: C25H28O6. Formula Weight: 424.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 244, 259, 316 nm. SMILES: OC1=C2C(OC(C=C(O)C(OC)=C3C/C=C(C)/C)=C3C2=O)=CC(OC)=C1C/C=C(C)/C. InChi Code: InChI=1S/C25H28O6/c1-13(2)7-9-15-18(29-5)12-20-22(23(15)27)24(28)21-16(10-8-14(3)4)25(30-6)17(26)11-19(21)31-20/h7-8,11-12,26-27H,9-10H2,1-6H3. InChi Key: YRKKJHJIWCRNCW-UHFFFAOYSA-N. Origin: Plant/Garcinia mangostana (mangosteen).