BEBT-908

Description: BEBT-908 (PI3Kalpha inhibitor 1) is a selective PI3Kalpha inhibitor with an IC50 of less than 0.1 µM and also inhibits HDAC with an IC50 ranging from 0.1 µM to 1 µM. Target: HDAC, PI3K. Smiles: CNc1ccc(cn1)-c1nc(N2CCOCC2)c2sc(CN(C)c3ncc(cn3)C(=O)NO)cc2n1. References: Cai Xiong, et al. Deazapurines, thienopyrimidines and furopyrimidines as phosphoinositide 3-kinase inhibitors with a zinc binding moiety and their preparation and use in the treatment of diseases. From U.S. Pat. Appl. Publ. (2012), US 20120088764 A1 20120412.