(±)-BAY 41-4109

(±)-BAY 41-4109 is a heteroaryldihydropyrimidine with antiviral activity. It inhibits hepatitis B virus (HBV) replication in HepG2.2.15 cells (IC50 = 202 nM) without affecting cell growth. (±)-BAY 41-4109 (25 mg/kg) reduces viral replication and viral load in a humanized mouse model of HBV infection.Formal Name: 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid, methyl ester. CAS Number: 298708-79-9. Molecular Formula: C18H13ClF3N3O2. Formula Weight: 395.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 210, 277 nm. SMILES: FC1=CC(F)=C(C2=NC(C)=C(C(OC)=O)C(C3=CC=C(F)C=C3Cl)N2)N=C1. InChi Code: InChI=1S/C18H13ClF3N3O2/c1-8-14(18(26)27-2)15(11-4-3-9(20)5-12(11)19)25-17(24-8)16-13(22)6-10(21)7-23-16/h3-7,15H,1-2H3,(H,24,25). InChi Key: FVNJBPMQWSIGJK-UHFFFAOYSA-N.