BAY-1797

BAY-1797 is an antagonist of the purinergic P2X4 receptor (IC50 = 0.211 µM for the human receptor). It is selective for P2X4 over P2X1, P2X3, and P2X7 receptors (IC50s = >50, 8.3, and 10.6 µM, respectively, for the human receptors), as well as a panel of G protein-coupled receptors (GPCRs), ion channels, kinases, and transporters at 10 µM. BAY-1797 (50 mg/kg) decreases intraplantar prostaglandin E2 (PGE2, Cay-14010) levels and reduces non-evoked pain-related behavior in the dynamic weight bearing test in a mouse model of inflammatory pain induced by complete Freund's adjuvant (CFA).Formal Name: N-[3-(aminosulfonyl)-4-(3-chlorophenoxy)phenyl]-benzeneacetamide. CAS Number: 2055602-83-8. Molecular Formula: C20H17ClN2O4S. Formula Weight: 416.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: O=C(CC1=CC=CC=C1)NC2=CC=C(C(S(=O)(N)=O)=C2)OC3=CC(Cl)=CC=C3. InChi Code: InChI=1S/C20H17ClN2O4S/c21-15-7-4-8-17(12-15)27-18-10-9-16(13-19(18)28(22,25)26)23-20(24)11-14-5-2-1-3-6-14/h1-10,12-13H,11H2,(H,23,24)(H2,22,25,26). InChi Key: CSJYMAFXYMYNCK-UHFFFAOYSA-N.