Azilsartan Medoxomil

Azilsartan medoxomil is a prodrug form of azilsartan (Cay-26091), a potent and selective angiotensin II receptor 1 (AT1) antagonist. Azilsartan medoxomil (0.1-10 mg/kg) reduces blood pressure and decreases plasminogen activator inhibitor 1 (PAI-1) levels in the plasma, left ventricle, and aortic wall in mice in a dose-dependent manner. It also inhibits the pressor response induced by angiotensin II (Cay-17150) in normotensive rats (ID50 = 0.12 mg/kg) and reduces blood pressure and improves glucose infusion, a marker of insulin sensitivity, in spontaneously hypertensive rats. Azilsartan medoxomil also has more potent antiproteinuric effects in Wistar fatty rats than olmesartan medoxomil (Cay-11614). Formulations containing azilsartan medoxomil have been used in the treatment of hypertension.Formal Name: 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester. CAS Number: 863031-21-4. Synonyms: TAK-491. Molecular Formula: C30H24N4O8. Formula Weight: 568.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CCOC1=NC2=CC=CC(C(OCC(O3)=C(C)OC3=O)=O)=C2N1CC4=CC=C(C5=C(C6=NOC(N6)=O)C=CC=C5)C=C4. InChi Code: InChI=1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36). InChi Key: QJFSABGVXDWMIW-UHFFFAOYSA-N.