Azelaprag

Description: Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases. Target: Apelin receptor. Smiles: N(S([C@H]([C@H](C)C=1N=CC(C)=CN1)C)(=O)=O)C=2N(C(=NN2)C=3C=C(C)C=NC3)C4=C(OC)C=CC=C4OC. References: Burstein AH, et al. Development of Azeliragon, an Oral Small Molecule Antagonist of the Receptor for Advanced Glycation Endproducts, for the Potential Slowing of Loss of Cognition in Mild Alzheimer's Disease. J Prev Alzheimers Dis. 2018,5(2):149-154.