AZ-PFKFB3-67

AZ-PFKFB3-67 is an inhibitor of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3 (PFKFB3, IC50 = 0.011 µM). It is selective for PFKFB3 over PFKFB1 and PFKFB2 (IC50s = 1.13 and 0.159 µM). It inhibits the formation of fructose-1,6-bisphosphate in A549 cells (IC50 = 0.281 µM). SMILES O=C(NC1=CC=C(OC2=CC=C3N(CC4=C(ON=C4C)C)C=C(C#N)C3=C2)C=C1)[C@@H]5CCCN5 InChi Code InChI=1S/C26H25N5O3/c1-16-23(17(2)34-30-16)15-31-14-18(13-27)22-12-21(9-10-25(22)31)33-20-7-5-19(6-8-20)29-26(32)24-4-3-11-28-24/h5-10,12,14,24,28H,3-4,11,15H2,1-2H3,(H,29,32)/t24-/m0/s1 InChi Key NDIKFKQBWGMLCA-DEOSSOPVSA-N