Australine (hydrochloride)

Description: Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 µM) that also inhibits glucosidase I, sucrase, maltase, andA. nigeralpha-glucosidase (IC50s = 20, 28, 35, and 28 µM, respectively).2,3Australine is selective for these enzymes over glucosidase II, alpha- and beta-mannosidase, and alpha- and beta-galactosidase up to 500 µM, beta-glucosidase, with only 5% inhibition at 66 µM, as well as isomaltase and trehalase (IC50= 97 and 160 µM, respectively). Australine (500 µg/ml) inhibits glycoprotein processing of viral glycoproteins in influenza virus-infected MDCK cells and induces the accumulation of glycoproteins.2. Target: Others. Smiles: Cl.[H][C@]12[C@@H](O)CCN1[C@H](CO)[C@@H](O)[C@@H]2O. References: Molyneux, R.J., Benson, M., Wong, R.Y., et al.Australine, a novel pyrrolizidine alkaloid glucosidase inhibitor from Castanospermum australJ. Nat. Prod.51(6)1198-1206(1988)