Aurintricarboxylic Acid (ammonium salt)

Aurintricarboxylic acid (ATA) is an inhibitor of protein synthesis that has diverse biological activities. It inhibits the activity of a variety of enzymes, including the nucleases DNase I, RNase A, and S1, as well as the serine proteases trypsin and chymotrypsin in a concentration-dependent manner. ATA inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV, EC50 = 200 µg/ml) and human enterovirus 71 in Vero cells (EV71, EC50 = 2.9 µM), as well as reduces HIV-1- or HIV-2-induced cytopathogenicity in MT-4 cells (IC50s = 1.1 and 0.85 µg/ml, respectively). It inhibits apoptosis induced by sanguinarine (Cay-16951) in K562 leukemia cells when used at a concentration of 100 µM. ATA (20 mg/kg, i.p.) decreases CNS CD4+ T cell infiltration and reduces hind limb weakness and paralysis in a mouse model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE).Formal Name: 3,3'-[(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis[6-hydroxy-benzoic acid, triammonium salt. CAS Number: 569-58-4. Synonyms: ATA. Molecular Formula: C22H11O9 . 3NH4. Formula Weight: 473.4. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 100 µg/ml. lambdamax: 214 nm. SMILES: [O-]C(C(C(C=C/1)=O)=CC1=C(C2=CC=C(O)C(C([O-])=O)=C2)\C3=CC=C(O)C(C([O-])=O)=C3)=O.[NH4+].[NH4+].[NH4+]. InChi Code: InChI=1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31,,,/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31),3*1H3. InChi Key: AIPNSHNRCQOTRI-UHFFFAOYSA-N.