ATP synthase inhibitor 1

Description: ATP synthase inhibitor 1 is an inhibitor of the c subunit of the F1/FO-ATP synthase complex. It inhibits mitochondrial permeability transition pore (mPTP) opening and does not affect ATP levels. Target: ATPase. Smiles: Clc1ccc(s1)S(=O)(=O)N1CCC2(CC1)N(CNC2=O)c1ccccc1. References: Morciano G, et al. Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction. J Med Chem. 2018 Aug 23,61(16):7131-7143.