AT-511 (hemisulfate)

AT-511 is a prodrug form of the antiviral nucleoside analog AT-9010. It reduces the infectious virus yield in cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome CoV (SARS-CoV), SARS-CoV-2, human CoV 229E (HCoV-229E), and HCoV-OC43 (EC90s = 37, 0.47, 2.8, 1.2, and 0.5 µM, respectively).Formal Name: N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-L-alanine, 1-methylethyl ester, hemisulfate. CAS Number: 2241337-84-6. Synonyms: AT-527 (hemisulfate), RO7496998. Molecular Formula: C24H33FN7O7P . 1/2H2SO4. Formula Weight: 630.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=S(O)(O)=O.CC(C)OC([C@H](C)N[P@](OC[C@@H]1[C@@H](O)[C@](F)(C)[C@]([H])(N2C=NC3=C(NC)N=C(N)N=C32)O1)(OC4=CC=CC=C4)=O)=O. InChi Code: InChI=1S/2C24H33FN7O7P.H2O4S/c2*1-13(2)37-21(34)14(3)31-40(35,39-15-9-7-6-8-10-15)36-11-16-18(33)24(4,25)22(38-16)32-12-28-17-19(27-5)29-23(26)30-20(17)32,1-5(2,3)4/h2*6-10,12-14,16,18,22,33H,11H2,1-5H3,(H,31,35)(H3,26,27,29,30),(H2,1,2,3,4)/t2*14-,16+,18+,22+,24+,40-,/m00./s1. InChi Key: QIGYBLSWYRTXCA-NVSCJZCKSA-N.