Aspergillin PZ

Aspergillin PZ is a fungal metabolite originally isolated from A. awamori. It induces morphological deformation of P. oryzae conidia when used at a concentration of 89 nM. Aspergillin PZ is active against S. epidermidis (MIC = 20 µM) but not S. aureus, E. coli, or B. cereus (MICs = >20 µM). It is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 µM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 µM).Formal Name: (1R,2S,5R,5aS,5bS,8R,8aS,9R,11aR,13aR)-2,3,4,5,5a,5b,8,8a,9,10,13,13a-dodecahydro-2-hydroxy-5,7,8-trimethyl-9-(2-methylpropyl)-1,5-epoxy-1H-cyclohepta[3,4]benz[1,2-d]isoindole-11,12-dione. CAS Number: 483305-08-4. Molecular Formula: C24H35NO4. Formula Weight: 401.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: CC1=C[C@@]([C@]2([H])[C@@](C3)([H])[C@@]4([H])[C@H](O)CC[C@@]2(O4)C)([H])[C@@]([C@@]5([H])[C@@H]1C)(C(N[C@H]5CC(C)C)=O)C3=O. InChi Code: InChI=1S/C24H35NO4/c1-11(2)8-16-19-13(4)12(3)9-15-20-14(10-18(27)24(15,19)22(28)25-16)21-17(26)6-7-23(20,5)29-21/h9,11,13-17,19-21,26H,6-8,10H2,1-5H3,(H,25,28)/t13-,14+,15-,16+,17-,19+,20+,21+,23+,24-/m1/s1. InChi Key: AQZDMONQDXTWHN-XLFKICHRSA-N. Origin: Fungi/Aspergillus sp..