AS-041164

Description: AS-041164 is a selective and orally active PI3Kgamma isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kalpha, PI3Kbeta, and PI3Kdelta (IC50s of 240 nM, 1.45 µM, and 1.70 µM, respectively). It has anti-inflammatory effects. Target: PI3K. Smiles: O=C1NC(=O)\C(S1)=C\c1ccc2OCOc2c1. References: Chiara Ferrandi, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007 Sep,322(3):923-30.