Arylpiperazine 5k

Arylpiperazine 5k is an inhibitor of fatty acid transport protein 1 (FATP1, IC50 = 4.6 nM for the human protein). It reduces the accumulation of neutral and polar lipids in MDA-MB-231 breast cancer cells induced by linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) when used at a concentration of 12.5 µM. Arylpiperazine 5k (12.5 µM) decreases ATP (Cay-14498) and BODIPY-palmitate (Cay-26749) levels in BJAB human lymphoma cells with a deletion of CD37, which is also a negative regulator of fatty acid uptake, but not in wild-type BJAB cells. It induces cell death in MDA-MB-231, MCF-7, HCC1806, and BT474 human breast cancer cells when used at a concentration of 12.5 µM.Formal Name: 4-(5-fluoro-2-pyridinyl)-N-(4,5,6,7-tetrahydro-2-benzothiazolyl)-1-piperazineacetamide. CAS Number: 1431945-95-7. Synonyms: DS22420314. Molecular Formula: C18H22FN5OS. Formula Weight: 375.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: Slightly. SMILES: FC1=CC=C(N=C1)N2CCN(CC(NC3=NC(CCCC4)=C4S3)=O)CC2. InChi Code: InChI=1S/C18H22FN5OS/c19-13-5-6-16(20-11-13)24-9-7-23(8-10-24)12-17(25)22-18-21-14-3-1-2-4-15(14)26-18/h5-6,11H,1-4,7-10,12H2,(H,21,22,25). InChi Key: ORQHHLPTMSGMQT-UHFFFAOYSA-N.