Artemether

Artemether is an antiparasitic compound and a derivative of artemisinin (Cay-11816). It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.Formal Name: (3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin. CAS Number: 71963-77-4. Synonyms: (+)-Artemether, SM-224. Molecular Formula: C16H26O5. Formula Weight: 298.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 16 mg/ml. SMILES: CO[C@H]1O[C@@]2([H])[C@]3(OO4)[C@](CC[C@@H](C)[C@]3([H])CC[C@]4(C)O2)([H])[C@H]1C. InChi Code: InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1. InChi Key: SXYIRMFQILZOAM-HVNFFKDJSA-N. Origin: Plant/Artemisia annua.