AP 18

Description: AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 µM Cinnamaldehyde with an IC50 of 3.1 µM and 4.5 µM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 µM AITC in a concentration-dependent manner (IC50= 10.3 µM). Target: TRP/TRPV Channel. Smiles: C\C(=C/c1ccc(Cl)cc1)\C(\C)=N\O