Anidulafungin

Anidulafungin is a semisynthetic echinocandin antifungal. It inhibits 1,3-beta-D glucan synthase from several C. albicans clinical isolates (IC50s = 0.89-7.96 ng/ml for the wild-type enzyme). Anidulafungin is active against various Candida species, including C. albicans, C. parapsilosis, C. tropicalis, and C. guiillermondi (MICs = =0.03-4 µg/ml), as well as A. fumigatus (MIC90 = =0.03 µg/ml). It increases survival and decreases the severity of pulmonary lesions in A. fumigatus-infected neutropenic rabbits when administered at a dose of 10 mg/kg. Formulations containing anidulafungin have been used in the treatment of candidemia and candidiasis.Formal Name: 1-[(4R,5R)-4,5-dihydroxy-N2-[[4''-(pentyloxy)[1,1':4',1''-terphenyl]-4-yl]carbonyl]-L-ornithine]-echinocandin B. CAS Number: 166663-25-8. Synonyms: LY303366, VER-002. Molecular Formula: C58H73N7O17. Formula Weight: 1140.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 303 nm. SMILES: O=C1[C@@]([C@@H](O)[C@@H](C)C2)([H])N2C([C@@]([C@H](O)C)([H])NC([C@H]([C@H](O)[C@@H](O)C3=CC=C(O)C=C3)NC([C@@]4([H])N(C([C@H]([C@H](O)C)NC([C@@H](NC(C5=CC=C(C6=CC=C(C7=CC=C(OCCCCC)C=C7)C=C6)C=C5)=O)C[C@@H](O)[C@@H](O)N1)=O)=O)C[C@H](O)C4)=O)=O)=O. InChi Code: InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42. InChi Key: JHVAMHSQVVQIOT-MFAJLEFUSA-N.