Anhydroerythromycin A

Anhydroerythromycin A is a degradation product of the macrolide antibiotic erythromycin (Cay-16486). It is formed via degradation of erythromycin in acidic aqueous solutions in vitro as well as in vivo. Anhydroerythromycin A is active against S. aureus and B. cereus in vitro (MICs = 12.5 and 6.25 µg/ml, respectively). It also inhibits steroid 6beta-hydroxylase activity associated with the cytochrome P450 (CYP) isoform CYP3A in human liver microsomes.Formal Name: 9-deoxo-6,12-dideoxy-6,9:9,12-diepoxy-erythromycin. CAS Number: 23893-13-2. Synonyms: BRL 46355ER, Erythromycin Anhydride. Molecular Formula: C37H65NO12. Formula Weight: 715.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: C[C@@H]1C[C@@]([C@H](O[C@@]2([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@@H](C)[C@H](O[C@@]3([H])C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@H]4C)(C)O[C@]51[C@H](C)[C@@H](O)[C@@](O5)(C)[C@@H](CC)OC4=O. InChi Code: InChI=1S/C37H65NO12/c1-14-25-36(10)29(40)22(6)37(50-36)18(2)16-35(9,49-37)31(48-33-27(39)24(38(11)12)15-19(3)44-33)20(4)28(21(5)32(42)46-25)47-26-17-34(8,43-13)30(41)23(7)45-26/h18-31,33,39-41H,14-17H2,1-13H3/t18-,19-,20+,21-,22-,23+,24+,25-,26+,27-,28+,29-,30+,31-,33+,34-,35-,36-,37+/m1/s1. InChi Key: YKAVHPRGGAUFDN-JTQLBUQXSA-N.