AM114

A 20S proteasome inhibitor (IC50 = ~1 µM), induces the accumulation of ubiquitinated proteins in HCT116 colon cancer cells at 1 µM, sensitizes HCT116 p53+/+ and HCT116 p53-/- cells to ionizing radiation-induced cytotoxicity in an additive and synergistic manner, respectively, decreases the viability of macrophages isolated from patients with rheumatoid arthritis (IC50 = 0.88 µM). Formulation: A solid. InChI: InChI=1S/C20H21B2NO5/c1-23-12-16(10-14-2-6-18(7-3-14)21(25)26)20(24)17(13-23)11-15-4-8-19(9-5-15)22(27)28/h2-11,25-28H,12-13H2,1H3. InChIKey: SRPIKXGUPAKTIZ-UHFFFAOYSA-N. SMILES: OB(C1=CC=C(C=C(CN(CC2=CC(C=C3)=CC=C3B(O)O)C)C2=O)C=C1)O