Alverine (citrate)

Alverine is an antispasmodic agent. It suppresses contractions induced by potassium or acetylcholine (ACh), but increases spontaneous contractions, in isolated guinea pig detrusor smooth muscle. Alverine blocks spontaneous and vagal-stimulated colonic motility in rabbits. Alverine (75 µg/animal) reduces the number of abdominal contractions induced by 5-hydroxy-L-tryptophan (5-HTP, Cay-20539) or high volume (1.6 ml) rectal distension in rats. Formulations containing alverine have been used in the treatment of functional gut disorders.Formal Name: N-ethyl-N-(3-phenylpropyl)-benzenepropanamine, mono-2-hydroxy-1,2,3-propanetricarboxylate. CAS Number: 5560-59-8. Synonyms: NSC 35459. Molecular Formula: C20H27N . C6H8O7. Formula Weight: 473.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: slightly soluble, PBS (pH 7.2): 1 mg/ml. SMILES: CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.OC(CC(C(O)=O)(O)CC(O)=O)=O. InChi Code: InChI=1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20,7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3,13H,1-2H2,(H,7,8)(H,9,10)(H,11,12). InChi Key: RYHCACJBKCOBTJ-UHFFFAOYSA-N.