alpha-Truxillic Acid

alpha-Truxillic acid can be formed by the dimerization of two molecules of alpha-trans-cinnamic acid. It is related to incarvillateine, a natural antinociceptive compound derived from the Asian herb I. sinensis. alpha-Truxillic acid and some of its derivatives significantly block inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice. Related compounds, like SB-FI-26 (Cay-14191), bind fatty acid binding protein 5 (FABP5). This may be related to pain suppression, since FABP5 acts as a transporter of the endocannabinoid anandamide. While certain derivatives of alpha-truxillic acid can directly activate peroxisome proliferator-activated receptor gamma, alpha-truxillic acid has no such activity.Formal Name: (1alpha,2alpha,3beta,4beta)-2,4-diphenyl-1,3-cyclobutanedicarboxylic acid. CAS Number: 490-20-0. Synonyms: Gratissimic Acid. Molecular Formula: C18H16O4. Formula Weight: 296.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2)(1:12): 0.07 mg/ml. lambdamax: 259 nm. SMILES: OC([C@H]1[C@H](C2=CC=CC=C2)[C@H](C(O)=O)[C@H]1C3=CC=CC=C3)=O. InChi Code: InChI=1S/C18H16O4/c19-17(20)15-13(11-7-3-1-4-8-11)16(18(21)22)14(15)12-9-5-2-6-10-12/h1-10,13-16H,(H,19,20)(H,21,22)/t13-,14-,15-,16-. InChi Key: QWFRRFLKWRIKSZ-BIAGXBKMSA-N.