alpha-Tocotrienol

alpha-Tocotrienol is an antioxidant and a form of vitamin E that has been found in rice bran and has neuroprotective properties. It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Cay-82220), or L-buthionine-(S,R)-sulfoximine (BSO, Cay-14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM. Cytosolic microinjection of alpha-tocotrienol prevents glutamate-induced cell death and phosphorylation of 12-lipoxygenase (12-LO) in HT4 neurons. It reduces glutamate-induced cytosolic and mitochondrial production of reactive oxygen species (ROS), accumulation of N-terminally truncated Bcl-xL (DeltaN-Bcl-xL), and cell death in primary rat hippocampal neurons. alpha-Tocotrienol (50 mg/kg) reduces infarct size in a spontaneously hypertensive rat model of stroke induced by tandem right common carotid artery and middle cerebral artery occlusion. [Matreya, LLC. Catalog No. 2109]Formal Name: 3,4-dihydro-2,5,7,8-tetramethyl-2R-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl)]-2H-1-benzopyran-6-ol. CAS Number: 58864-81-6. Molecular Formula: C29H44O2. Formula Weight: 424.7. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 289 nm. SMILES: C[C@]1(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)OC2=C(C)C(C)=C(O)C(C)=C2CC1. InChi Code: InChI=1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1. InChi Key: RZFHLOLGZPDCHJ-XZXLULOTSA-N.