alpha-NETA

Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer's disease, and multiple sclerosis. alpha-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 µM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. alpha-NETA is commonly used in cells in culture.Formal Name: N,N,N-trimethyl-gamma-oxo-2-naphthalenepropanaminium, monoiodide. CAS Number: 31059-54-8. Molecular Formula: C16H20NO . I. Formula Weight: 369.2. Purity: >97%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 3mg/ml, Methanol: Soluble. SMILES: O=C(CC[N+](C)(C)C)C1=CC2=CC=CC=C2C=C1.[I-]. InChi Code: InChI=1S/C16H20NO.HI/c1-17(2,3)11-10-16(18)15-9-8-13-6-4-5-7-14(13)12-15,/h4-9,12H,10-11H2,1-3H3,1H/q+1,/p-1. InChi Key: LIFHUGCXEAQKRZ-UHFFFAOYSA-M.