alpha-Ketoglutaric Acid

alpha-Ketoglutaric acid is an alpha-keto acid and a rate-determining metabolic intermediate in the citric acid cycle in its conjugate base form, alpha-ketoglutarate. It is formed via oxidative decarboxylation of isocitrate by isocitrate dehydrogenase (IDH), oxidative deamination of glutamate by glutamate dehydrogenase, or by pyridoxal phosphate-dependent transamination. alpha-Ketoglutaric acid is decarboxylated to succinyl-CoA by alpha-ketoglutarate dehydrogenase, a rate limiting step in the citric acid cycle. It is a precursor of glutamine and glutamate, energy sources for enterocytes and various immune cells, and an antioxidant with roles in immune homeostasis, aging, protein synthesis, and bone development.Formal Name: 2-oxo-pentanedioic acid. CAS Number: 328-50-7. Synonyms: alpha-KGA, NSC 17391, 2-Oxoglutaric Acid. Molecular Formula: C5H6O5. Formula Weight: 146.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(C(CCC(O)=O)=O)O. InChi Code: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10). InChi Key: KPGXRSRHYNQIFN-UHFFFAOYSA-N.