Aloin

Aloin is a mixture of aloin A and aloin B (Cay-23321), anthraquinones found in Aloe vera, and has diverse biological activities. It reduces IL-6 and TNF-alpha expression as well as nitric oxide (NO) production and COX-2 and inducible NO synthase (iNOS) expression in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 100 to 400 mM. Aloin inhibits LPS-induced p65 acetylation, nuclear translocation of NF-kB, and apoptosis in RAW 264.7 cells. It reduces motility of T. congolense in vitro and reduces the number of parasites in T. congolense-infected mice when administered at a dose of 400 mg/kg. Aloin (50 and 100 mg/kg) also reduces activity of glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR), the level of colonic malondialdehyde (MDA), and the number of aberrant crypt foci and mucin-depleted foci in a rat model of 1,2-dimethylhydrazine-induced colon cancer.Formal Name: 10-beta-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone. CAS Number: 452311-56-7. Molecular Formula: C21H22O9. Formula Weight: 418.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.25 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 245, 261, 269, 297, 361 nm. SMILES: O=C1C2=C(O)C=C(CO)C=C2C([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C4=C1C(O)=CC=C4. InChi Code: InChI=1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14?,17-,19+,20-,21+/m1/s1. InChi Key: AFHJQYHRLPMKHU-CGISPIQUSA-N.