Aldometanib (Iodide)

Aldometanib is an inhibitor of aldolase (IC50 = ~15 nM for lysosome-bound aldolase) and an activator of AMP-activated protein kinase (AMPK). It selectively activates lysosomal AMPK over cytosolic or mitochondrial AMPK at 5 nM. Aldometanib (50 µM) inhibits ferroptosis in H9c2 cardiomyocytes in an in vitro model of myocardial ischemia-reperfusion injury. It decreases blood glucose levels in lean mice, decreases blood glucose levels, fat mass, and hepatic lipid accumulation in high-fat diet-induced obese mice, and increases lifespan and healthspan in aged mice. Aldometanib (5 mg/kg) inhibits glycolysis, increases survival, and decreases disease progression in a mouse model of amyotrophic lateral sclerosis (ALS). It increases intratumoral CD8+ T cell infiltration in models of hepatocellular carcinoma (HCC) using immunocompetent but not immunodeficient mice.. SMILES: ClC1=CC=CC(Cl)=C1C[N+]2=C(C)N(CCCCCCCCCCCCCCCC)C=C2.[I-]. InChi Code: InChI=1S/C27H43Cl2N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-30-21-22-31(24(30)2)23-25-26(28)18-17-19-27(25)29,/h17-19,21-22H,3-16,20,23H2,1-2H3,1H/q+1,/p-1. InChi Key: QGSVKLIYXRLMTB-UHFFFAOYSA-M