Alda-1

Alda-1 is a selective aldehyde dehydrogenase 2 (ALDH2) agonist. This cell-permeable benzamide selectively enhances the activity of WT ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2-, and 11-fold increase in Vmax of 20 µg homozygous WT, heterozygous WT/mutant, and homozygous mutant tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Alda-1 (20 µM) protects against ex vivo ischemic tissue damage to excised rat hearts (25% and 24% reduction in infarct size and creatine phosphokinase (CPK) release, respectively). Alda-1 also, at a dose of 8.5 mg/kg, reduces infarct size by 60% in anesthetized live rats.Formal Name: N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichloro-benzamide. CAS Number: 349438-38-6. Molecular Formula: C15H11Cl2NO3. Formula Weight: 324.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml. SMILES: ClC1=C(C(NCC2=CC=C(OCO3)C3=C2)=O)C(Cl)=CC=C1. InChi Code: InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19). InChi Key: NMKJFZCBCIUYHI-UHFFFAOYSA-N.