Afatinib D6

Description: Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor. Smiles: N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4. References: Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7,27(34):4702-11.