AEG 3482

AEG 3482 is an inhibitor of p75NTR- and NRAGE-induced apoptosis. It inhibits JNK signaling, caspase-3 cleavage, and cell death induced by the p75 neurotrophin receptor (p75NTR) or the p75NTR-interacting protein NRAGE in PC12rtTA cells in a concentration-dependent manner. AEG 3482 inhibits cell death induced by withdrawal of nerve growth factor (NGF) in rat SCG neurons (EC50 = ~20 µM). It also increases Hsp70 and Hsp25 levels in mouse embryonic fibroblasts (MEFs) in an HSF1-dependent manner and binds to recombinant Hsp90.Formal Name: 6-phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide. CAS Number: 63735-71-7. Molecular Formula: C10H8N4O2S2. Formula Weight: 280.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMF: 17 mg/ml, DMSO: 17 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 258 nm. SMILES: NS(C1=NN2C(S1)=NC(C3=CC=CC=C3)=C2)(=O)=O. InChi Code: InChI=1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16). InChi Key: MQUYTXDAVCOCMX-UHFFFAOYSA-N.