Adefovir

Adefovir is an active metabolite of the antiviral nucleoside analog adefovir dipivoxil (Cay-28373). Adefovir is formed from adefovir dipivoxil by gastrointestinal carboxylesterase 2 (CES2). It inhibits cytopathogenicity induced by herpes simplex virus 1 (HSV-1) and HSV-2 (EC50 = 7 µg/ml for both in E6SM cells), HIV-1 and HIV-2 (EC50s = 1.8 and 2.5 µg/ml, respectively, in CEM cells), and varicella zoster virus (VZV, EC50 = 10 µg/ml in human embryonic lung fibroblasts). Adefovir (50 mg/kg, p.o.) reduces increases in lymph node viral DNA and serum IgG levels in a mouse model of AIDS induced by infection with the retroviral complex LP-BM5. It also inhibits tumor growth induced by Moloney sarcoma virus (MSV) infection in mice at the same dose.Formal Name: P-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-phosphonic acid. CAS Number: 106941-25-7. Synonyms: GS-0393, PMEA. Molecular Formula: C8H12N5O4P. Formula Weight: 273.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. SMILES: NC1=C2C(N(CCOCP(O)(O)=O)C=N2)=NC=N1. InChi Code: InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16). InChi Key: SUPKOOSCJHTBAH-UHFFFAOYSA-N.