ACU 4429 (hydrochloride)

ACU 4429 is an inhibitor of retinal pigment epithelium 65 (RPE65, IC50 = 4.4 nM), an enzyme that catalyzes the isomerization of 11-trans retinol to 11-cis retinol (Cay-33207) in the visual cycle. It reduces rod photoreceptor recovery in dark-adapted mice after photobleaching (ED50 = 0.21mg/kg) and reversibly decreases the regeneration of 11-cis retinal oxime in the same model (ED50 = 0.18 mg/kg). ACU 4429 also prevents light-induced photoreceptor cell loss in dark-adapted albino mice. It reduces lipofuscin autofluorescence and decreases the level of retinoid toxin (A2E) in the RPE in an Abca4-/- mouse model of Stargardt disease (ED50 = 0.47 mg/kg).Formal Name: (alphaR)-alpha-(2-aminoethyl)-3-(cyclohexylmethoxy)-benzenemethanol, monohydrochloride. CAS Number: 1141934-97-5. Molecular Formula: C16H25NO2 . HCl. Formula Weight: 299.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 222 nm. SMILES: NCC[C@H](C1=CC(OCC2CCCCC2)=CC=C1)O.Cl. InChi Code: InChI=1S/C16H25NO2.ClH/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13,/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2,1H/t16-,/m1./s1. InChi Key: BPZWRYOUJMDQSY-PKLMIRHRSA-N.