Acetyl Hexapeptide-3 (acetate)

Acetyl hexapeptide-3 is a synthetic acetylated and amidated hexapeptide consisting of amino acid residues 12-17 of synaptosomal-associated protein 25 (SNAP-25). It inhibits formation of the SNARE complex in vitro in a concentration-dependent manner. It also inhibits calcium-induced norepinephrine release in permeabilized chromaffin cells (IC50 = 110 µM). Acetyl hexapeptide-3 (10% in an oil-and-water emulsion) inhibits decreases in type I collagen levels and skin thickness, as well as increases in type III collagen levels, in skin in a mouse model of subacute aging induced by D-galactose (Cay-20890) when administered topically.Formal Name: N-acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide, acetate. Synonyms: Ac-EEMQRR-NH2, Acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2, Acetyl Hexapeptide-8. Molecular Formula: C34H60N14O12S . XC2H4O2. Formula Weight: 889.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OC(CC[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)CCSC)=O)CCC(O)=O)=O)=O.CC(O)=O. InChi Code: InChI=1S/C34H60N14O12S.C2H4O2/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38,1-2(3)4/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42),1H3,(H,3,4)/t18-,19-,20-,21-,22-,23-,/m0./s1. InChi Key: KUOYHRQPSCEGDA-PXILYFGCSA-N.