Ac-IEPD-AFC

A fluorogenic substrate for granzyme B, AFC is released upon enzymatic cleavage by granzyme B and its fluorescence can be used to quantify granzyme B activity, ex/em = 400/505 nm, respectively. Formulation: A solid. InChI: InChI=1S/C32H38F3N5O11/c1-4-15(2)27(36-16(3)41)30(49)38-20(9-10-24(42)43)31(50)40-11-5-6-22(40)29(48)39-21(14-25(44)45)28(47)37-17-7-8-18-19(32(33,34)35)13-26(46)51-23(18)12-17/h7-8,12-13,15,20-22,27H,4-6,9-11,14H2,1-3H3,(H,36,41)(H,37,47)(H,38,49)(H,39,48)(H,42,43)(H,44,45)/t15-,20-,21-,22-,27-/m0/s1. InChIKey: HWXKKVLJPWMVLL-FGGUPADCSA-N. SMILES: O=C([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)[C@H](CC)C)=O)N1CCC[C@H]1C(N[C@H](C(NC2=CC=C3C(OC(C=C3C(F)(F)F)=O)=C2)=O)CC(O)=O)=O