AC-265347

AC-265347 is a calcimimetic and positive allosteric modulator of the calcium-sensing receptor (CaSR, EC50 = 7.94 nM in a cell-based phosphatidylinositol hydrolysis assay in the presence of calcium)., It inhibits the proliferation of NIH3T3 cells expressing human CaSR (EC50 = 25.12 nM). AC-265347 reduces plasma parathyroid hormone levels in rats (ED50 = 0.01 mg/kg).Formal Name: alpha-(2,4-dimethylphenyl)-alpha-methyl-2-benzothiazolemethanol. CAS Number: 1253901-26-6. Molecular Formula: C17H17NOS. Formula Weight: 283.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM. SMILES: CC1=CC(C)=CC=C1C(C)(O)C2=NC3=CC=CC=C3S2. InChi Code: InChI=1S/C17H17NOS/c1-11-8-9-13(12(2)10-11)17(3,19)16-18-14-6-4-5-7-15(14)20-16/h4-10,19H,1-3H3. InChi Key: IGSZVEPQZANNAB-UHFFFAOYSA-N.