AC-264613

Description: AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613(AC264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613(AC264613) activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM. Target: Protease-activated Receptor. Smiles: CC(=NNC(=O)[C@@H]1[C@H](CNC1=O)c1ccccc1)c1cccc(Br)c1. References: Cosimi E, et al. Stereoselective Synthesis of alpha-Fluoro-gamma-nitro Thioesters under Organocatalytic Conditions. Org Lett. 2016 Dec 2,18(23):6014-6017