ABL 127

ABL 127 is a covalent aza-beta-lactam inhibitor of protein phosphatase methylesterase-1 (PME-1, IC50 = 4.2 nM). It selectively inhibits PME-1 over 50 other serine hydrolases in MDA-MB-231 and HEK293T cell lysates at 10 µM. ABL 127 decreases proliferation of Ishikawa cells and migration of ECC-1 endometrial carcinoma cells when used at a concentration of 50 nM.Formal Name: (3R)-3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylic acid, 1,2-dimethyl ester. CAS Number: 1073529-41-5. Molecular Formula: C17H20N2O5. Formula Weight: 332.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: >5mg mL, Ethanol: >1mg/mL. SMILES: COC(N(N(C(OC)=O)[C@@]1(C2=CC=CC=C2)C3CCCC3)C1=O)=O. InChi Code: InChI=1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1. InChi Key: ZRHWCAFAIHTQKD-KRWDZBQOSA-N.