Abafungin

Abafungin is an antifungal agent. It is active against a variety of dermatophytes, yeast, molds, and other fungi (MICs = =0.06-2, 0.5-16, =0.06-1, and 0.25-8 µg/ml, respectively). Abafungin inhibits ergosterol biosynthesis, as well as acts directly on the fungal cell membrane to induce cell death.Formal Name: N-[4-[2-(2,4-dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine. CAS Number: 129639-79-8. Synonyms: BAY-W 6341. Molecular Formula: C21H22N4OS. Formula Weight: 378.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/mL, DMSO: 2.5 mg/mL, Ethanol: 0.3 mg/mL, PBS (pH 7.2): 0.3 mg/mL. lambdamax: 244, 301 nm. SMILES: CC1=CC(C)=CC=C1OC2=C(C=CC=C2)C3=CSC(NC4=NCCCN4)=N3. InChi Code: InChI=1S/C21H22N4OS/c1-14-8-9-18(15(2)12-14)26-19-7-4-3-6-16(19)17-13-27-21(24-17)25-20-22-10-5-11-23-20/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H2,22,23,24,25). InChi Key: TYBHXIFFPVFXQW-UHFFFAOYSA-N.