A-205804

A-205804 is a potent inhibitor of E-selectin and ICAM-1 expression in human vascular endothelial cells stimulated with TNF-alpha (IC50s = 20 and 25 nM, respectively). It does not block expression of VCAM-1 (IC50 > 1,000 nM).Formal Name: 4-[(4-methylphenyl)thio]-thieno[2,3-c]pyridine-2-carboxamide. CAS Number: 251992-66-2. Molecular Formula: C15H12N2OS2. Formula Weight: 300.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 15 mg/ml. lambdamax: 229, 340 nm. SMILES: O=C(N)C1=CC2=C(SC3=CC=C(C)C=C3)C=NC=C2S1. InChi Code: InChI=1S/C15H12N2OS2/c1-9-2-4-10(5-3-9)19-13-7-17-8-14-11(13)6-12(20-14)15(16)18/h2-8H,1H3,(H2,16,18). InChi Key: QQGWEXFLMJGCAL-UHFFFAOYSA-N.